The Talisman of Remedium is a bauble item added by Thaumic Tinkerer. It is worn in the amulet slot. When activated, it will take durability damage in exchange of removing negative effects from the player.
You have studied life and the body and found that through the application of magic you can protect yourself from harmful outside influences by redirecting these effects to a construct. This talisman will dispel most harmful effects on the holder and keep them on itself, taking damage.
To enable or disable this ability, one would shift-right click on it. As expected, it only works whilst enabled. It must be worn in your amulet slot to take effect.